Determination of Cefadroxil by Sequential Injection with Spectrophotometric Detector

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A sequential injection analysis (SIA) spectrophotometric procedure for cefadroxil determination has been developed. The SIA instrumentation was modified to achieve the desired function and operations by using the software developed to interface the PC with the conventional SIA system. The method is based on the measurement of a red, water-soluble product formed by the reaction between cefadroxil and 4-aminoantipyrine in the presence of alkaline potassium hexacyanoferrate(III) at 510 nm. Optimum conditions for determining the drug were investigated. Beer's law was obeyed over the concentration ranges of 1 - 10 mg L<sup>-1</sup> and 10 - 50 mg L<sup>-1</sup> with a detection limit (3 <i>σ</i>) of 0.17 mg L<sup>-1</sup> and a limit of quantification (10 <i>σ</i>) of 0.56 mg L<sup>-1</sup>. The relative standard deviations of 1.98% and 1.93% for 5 mg L<sup>-1</sup> and 30 mg L<sup>-1</sup> of the drug, respectively (<i>n</i> = 11) are obtained. The proposed method has been applied satisfactorily to the determination of cefadroxil in commercial pharmaceutical formulations with a sampling rate of 100 h<sup>-1</sup>. Results obtained were in good agreement with those obtained by the official HPLC method at the 95% confidence level.

収録刊行物

  • Analytical sciences : the international journal of the Japan Society for Analytical Chemistry  

    Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 22(4), 591-597, 2006-04-10 

    The Japan Society for Analytical Chemistry

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各種コード

  • NII論文ID(NAID)
    10018123983
  • NII書誌ID(NCID)
    AA10500785
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09106340
  • NDL 記事登録ID
    7872031
  • NDL 雑誌分類
    ZP4(科学技術--化学・化学工業--分析化学)
  • NDL 請求記号
    Z54-F482
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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