Oxovanadium (IV) and (V) Complexes with 3-Hydroxy-4(1H)-pyridinones and 1-Hydroxy-2(1H)-pyrimidinones--Synthesis, Structural Characteristics, and Their Insulin-mimetic Activities (特集:糖尿病と金属) Oxovanadium (IV) and (V) Complexes with 3-Hydroxy-4(1H)-pyridinones and 1-Hydroxy-2(1H)-pyrimidinones - Synthesis, Structural Characteristics, and Their Insulin-mimetic Activities

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Five kinds of <I>N</I>-substituted 3-hydroxy-2-methyl-4(1<I>H</I>)-pyridinones, and three kinds of 1-hydroxy-2(1<I>H</I>)-pyrimidinones were synthesized. Treatment of 3-hydroxy-4(1<I>H</I>)-pyridinones with VO(acac)<SUB>2</SUB> in CH<SUB>3</SUB>OH exclusively gave CH<SUB>3</SUB>O-coordinated oxovanadium (V) complexes. On the other hand, treatment with VOSO<SUB>4</SUB> in H<SUB>2</SUB>O at pH 10 for 3-hydroxy-4(1<I>H</I>)-pyridinones and at pH 7 for 1-hydroxy-2(1<I>H</I>)-pyrimidinones afforded the corresponding oxovanadium (IV) complexes. These complexes were fully characterized by means of IR, UV-vis, <SUP>1</SUP>H-and <SUP>51</SUP>V-NMR, FAB-MS, ESR spectroscopies, and combustion analysis. From the result of the inhibitory effect of oxovanadium (IV) complexes on free fatty acid (FFA) release from rat adipocytes treated with epinephrine in the presence of glucose <I>in vitro</I>, it was revealed that bis(1,2-dihydro-4,6-dimethyl-2-oxo-1-pyrimidinolato)oxovanadium (IV) showed the highest insulin-mimetic activity. Furher, the <I>in vivo</I> insulin-mimetic activity was evaluated with streptozotocin (STZ)-induced diabetic rats. Blood glucose levels were substantially lowered from hyperglycemic to nomal levels after the treatment with bis (1,2-dihydro-4,6-dimethyl-2-oxo-1-pyrimidinolato) oxovanadium (IV) by daily intraperitoneal injections.

収録刊行物

  • Biomedical research on trace elements  

    Biomedical research on trace elements 17(1), 1-10, 2006-04-01 

    Japan Society for Biomedical Research on Trace Elements

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各種コード

  • NII論文ID(NAID)
    10018127338
  • NII書誌ID(NCID)
    AN10423256
  • 本文言語コード
    ENG
  • 資料種別
    REV
  • ISSN
    0916717X
  • NDL 記事登録ID
    7927334
  • NDL 雑誌分類
    ZS8(科学技術--医学--解剖学・生理学・生化学)
  • NDL 請求記号
    Z19-3255
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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