Different Effects of the Soy Isoflavones, Genistein and Daidzein, on Pregnant and Lactating Rats and Their Offspring

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  • 妊娠期・授乳期の母親ラット，仔ラットに対するゲニステインとダイゼイン投与における生体影響の相違
  • ニンシンキ ジュニュウキ ノ ハハオヤ ラット シラット ニ タイスル ゲニステイン ト ダイゼイン トウヨ ニ オケル セイタイ エイキョウ ノ ソウイ

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Abstract

The objects of the present study were to confirm the safety and compare the effects of the soy isoflavones, genistein and daidzein, on rat dams and their offspring. Sprague-Dawley rats were fed with a control diet or diet containing 0.50g/kg of genistein or daidzein during pregnancy and the lactation period until postnatal day 12. The body weight of the dams fed with the daidzein diet was significantly suppressed during pregnancy and lactation, and the litter weight of the daidzein group was significantly lower at birth compared to the control group and genistein group. The body weight of the offspring during lactation and after weaning was also significantly suppressed in the daidzein group. On the other hand, the body and wet organ weights, dry weight of the femur and anogenital distance in the offspring were not affected by exposure to genistein or daidzein.<br>Equol was found in the stomach milk and serum of the suckling pups in the daidzein group. The possibility is suggested that equol might have contributed to the obvious effects observed in the daidzein group.

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