The new phase of transcriptome analysis.

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  • ゲノミクス・プロテオミクスを中心に‐ｏｍｉｃｓへの電気泳動法の応用　　ゲノム科学新時代に向けて
  • ゲノム カガク シン ジダイ ニ ムケテ

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Abstract

The FANTOM Consortium analyzed over 2 million sequences of RNAs produced from the mouse genome, obtaining more than 100, 000 full length copies of these RNAs, and used several new technologies to generate more than 20 million tags representing their starts and ends in a technical tour-de-force that provides a amazing new view of our genome. These studies clearly indicate that while proteins comprise the essential components of our cells, the development of multicellular organisms like mammals is controlled by vast amounts of regulatory noncoding RNAs that until recently have not been suspected to exist or be relevant to biology. Moreover, since most proteins are similar among mammals it also suggests that many of the differences between species may be embedded in differences in the RNA regulatory control systems, which are evolving much faster than the protein components. If correct, these findings will radically alter our understanding of genetics and how information is stored in our genome, and how this information is transacted to control the incredibly complex process of mammalian development, with major implications for the future of biological research, medicine and biotechnology.

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