Human Papillomavirus (HPV) 16感染をともなった肛門管扁平上皮内癌の1例 [in Japanese] Squamous Cell Carcinoma In Situ of the Anal Canal with Human Papillomavirus (HPV) 16 infection-Report of a Case [in Japanese]
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症例は65歳女性,排便時肛門出血を主訴に受診.大腸内視鏡検査で肛門管後壁,歯状腺直上に15×15mm大の赤色扁平隆起を認め,インジゴカルミン散布後の近接観察で,腫瘤表面の絨毛状構造と大小不同の著明な血管増生像を認めた.腰麻下,経肛門的に局所切除術施行.病理学的検索により低分化扁平上皮内癌(squamous cell carcinoma in situ: CIS)と診断した.またPolymerase chain reaction(PCR)法にて,悪性腫瘍関連型(高リスク型)のHuman PapillomavirusであるHPV16が検出された.
A 65-year old woman was referred to our hospital because of hematochezia. Colonoscopy revealed a flat elevated lesion, 15mm in diameter, that was reddish with contact-bleeding, at the dentate line on the posterior wall of the lower rectum (Rb) to the anal canal. Detailed observation by a closed view after indigo carmine dye spraying clearly demonstrated a villous surface structure and remarkable vessel overgrowth making a tumor that varied in size and shape. Transanal resection was performed under spinal anesthesia. The final histological diagnosis of the resected lesion was poorly differentiated squamous cell carcinoma in situ. The polymerase chain reaction (PCR) method detected human papilloma virus (HPV) 16, which is thought to be one of the most oncogenic HPV types.
- The Japanese journal of proctology
The Japanese journal of proctology 59(5), 270-275, 2006-05-01
The Japan Society of Coloproctology