An Anti-Salmonella Antibody Prevents the Salmonella enterica serovar Enteritidis from Infecting the Human Intestinal Epithelial Cell Line, Caco-2, by Interacting with Flagella

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著者

    • IGIMI Shizunobu
    • Division of Biomedical Food Research, National Institute of Health Sciences
    • YAMASAKI Manabu
    • Division of Biomedical Food Research, National Institute of Health Sciences
    • KAJIKAWA Akinobu
    • Division of Biomedical Food Research, National Institute of Health Sciences
    • YAMAMOTO Shigeki
    • Division of Biomedical Food Research, National Institute of Health Sciences
    • AMANO Fumio
    • Laboratory of Physiological Chemistry, Osaka University of Pharmaceutical Sciences

抄録

A polyclonal antibody of <i>Salmonella enterica</i> serovar Enteritidis (SE), designated RY542, inhibited SE from attaching to and invading the human intestinal epithelial cell line, Caco-2, in a dose-dependent manner. A major immunoreactive band of 55 kDa obtained in western blotting using RY542 was identified as FliC. An affinity-purified anti-flagellin antibody from RY542 similarly inhibited the infection. These results suggest that RY542 is a neutralizing antibody that blocks the infection of SE in Caco-2 cells by interacting with flagella, and that flagellin may potentially be useful as a component of a <i>Salmonella</i> vaccine.<br>

収録刊行物

  • Bioscience and microflora  

    Bioscience and microflora 25(3), 117-119, 2006-07-01 

    JAPAN BIFIDUS FOUNDATION

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各種コード

  • NII論文ID(NAID)
    10018168703
  • NII書誌ID(NCID)
    AA1108739X
  • 本文言語コード
    ENG
  • 資料種別
    NOT
  • ISSN
    13421441
  • データ提供元
    CJP書誌  J-STAGE 
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