書誌事項
- タイトル別名
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- Improved Stability of OPALMON<sup>®</sup> Tablets under Humid Conditions: The Effect of Dextran and Dextrin as Stabilizing Additives
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抄録
<p>The stability of OPALMON® tablets, which contain the active ingredient Limaprostalfadex, a PGE1 derivative, is known to be affected by humidity. In this study, we sought to investigate methods to improve the stability of OPALMON® tablets under humid conditions. Polysaccharide additives, such as dextran, exhibited a stabilizing effect under humid conditions, while disaccharide additives, such as lactose, had no effect. Under humid conditions, the lyophilized drug product containing a disaccharide additive was liquefied. In contrast, the appearance of the product containing dextran was unchanged. Dextran and dextrin provided the best stabilization of this drug product in comparison with other saccharide and cellulose additives.</p><p>The pH of the lyophilized product mixed with various additives did not affect stability, regardless of the additives used. The moisture content of the product containing dextran or dextrin was higher than that of the product mixed with other additives, suggesting that the moisture content of the lyophilized product does not affect the stability of Limaprost-alfadex. Therefore, the mechanism of stabilization by dextran and dextrin remains to be elucidated. Differences in the mobility of water molecules between dextran and dextrin and other additives are likely to play a role in the stabilization of Limaprost-alfadex.</p>
収録刊行物
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- 薬剤学
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薬剤学 66 (2), 160-166, 2006
公益社団法人 日本薬剤学会
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詳細情報 詳細情報について
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- CRID
- 1390845713061142656
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- NII論文ID
- 10018170011
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- NII書誌ID
- AN00266708
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- ISSN
- 21883149
- 03727629
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可