The mechanisms of antinuclear antibody production and its pathogenicity in systemic autoimmune diseases

• FUJII Takao

  Department of Rheumatology, and Clinical Immunology Graduate School of Medicine, Kyoto University

Bibliographic Information

Other Title

• 自己抗体の産生機序とその病原性　　こう原病における抗核抗体の産生機序とその病原性

Abstract

  Genesis of antinuclear antibodies is one of the most important immunological abnormalities that are closely associated with clinical manifestations, disease activity, and prognosis of systemic autoimmune diseases. Previous reports indicated that autoreactive T cells have critical roles not only in antinuclear antibody production but also in organ damages. Recently, the possible molecules that are involved in the mechanism of antinuclear antibody production have been determined by using lupus-prone mice. Target treatment against the key molecules associated with autoreactive T cells and B cells may be the useful therapeutic strategy for systemic autoimmune diseases along with the suppression of disease-specific antinuclear antibody production.<br>

Journal

• Japanese Journal of Clinical Immunology

  Japanese Journal of Clinical Immunology 29 (2), 57-64, 2006

  The Japan Society for Clinical Immunology

Keywords

• antinuclear antibodies
• systemic lupus erythematosus
• autoreactive T cells
• MRL/<i>lpr</i> mice

Details

• CRID: 1390282679625688576
• NII Article ID: 10018171273
• NII Book ID: AN00357971
• DOI: 10.2177/jsci.29.57
• ISSN: 13497413
• ISSN: 09114300
• Web Site: http://www.jstage.jst.go.jp/article/jsci/29/2/29_2_57/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2006161585
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed