Anti-neutrophil Cytoplasmic Antibody MPO-ANCA related with Disease Activity of Vasculitis

• SUZUKI Kazuo

  Department of Bioactive Molecules, National Institute of Infectious Diseases

Bibliographic Information

Other Title

• 自己抗体の産生機序とその病原性　　好中球自己抗体ＭＰＯ‐ＡＮＣＡの病原性と血管炎の病態

Abstract

  Myeloperoxidase (MPO)-specific anti-neutrophil cytoplasmic antibodies (MPO-ANCA) are involved in the development of vasculitis microscopic polyangiitis, a systemic vasculitis etc. We have showed a correlation of MPO-ANCA epitopes in vasculitis concerning contribution of N and C terminus of MPO to severity of the diseases. On the other hand, a role of activated neutrophils in inflammatory nephritis renal lesions using SCG/Kj mice. In the phase of nephritis with a low grade of proteinuria, the spontaneous release of MPO from peripheral neutrophils increased, indicating that neutrophils are activated and contribute to the development of active crescentic lesions in SCG/Kj mice. In addition, we have investigated that mice having CADS/CAWS-induced vasculitis also are good model animals for the analysis of the production of MPO-ANCA. Furthermore, we have clarified that MPO is a major antigen for MPO-ANCA production using MPO knock mice.<br>

Journal

• Japanese Journal of Clinical Immunology

  Japanese Journal of Clinical Immunology 29 (2), 94-101, 2006

  The Japan Society for Clinical Immunology

Keywords

• MPO-ANCA
• Myeloperpxidase (MPO)
• activated neutrophils
• rapid progressive glomerulo nephritis
• cororary arteritis

Details

• CRID: 1390001204648985600
• NII Article ID: 10018171456
• NII Book ID: AN00357971
• DOI: 10.2177/jsci.29.94
• ISSN: 13497413
• ISSN: 09114300
• Web Site: http://www.jstage.jst.go.jp/article/jsci/29/2/29_2_94/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2006161589
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed