Deep vein thrombosis and pulmonary embolism in a patient with multiple myeloma treated with thalidomide and dexamethasone

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  • MIYAZAWA Yuri
    Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine
  • IRISAWA Hiroyuki
    Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine
  • UCHIUMI Hideki
    Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine
  • SAITOH Takayuki
    Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine
  • HANDA Hiroshi
    School of Health Sciences, Faculty of Medicine, Gunma University
  • MATSUSHIMA Takafumi
    Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine
  • TSUKAMOTO Norifumi
    Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine
  • KARASAWA Masamitsu
    Division of Blood Transfusion, Gunma University Hospital
  • MURAKAMI Hirokazu
    School of Health Sciences, Faculty of Medicine, Gunma University
  • NOJIMA Yoshihisa
    Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine

Bibliographic Information

Other Title
  • Thalidomide, dexamethasone併用療法中に深部静脈血栓症, 肺動脈塞栓症を発症した多発性骨髄腫
  • 症例報告 Thalidomide, dexamethasone併用療法中に深部静脈血栓症,肺動脈塞栓症を発症した多発性骨髄腫
  • ショウレイ ホウコク Thalidomide dexamethasone ヘイヨウ リョウホウ チュウ ニ シンブ ジョウミャク ケッセンショウ ハイ ドウミャク ソクセンショウ オ ハッショウ シタ タハツセイ コツズイシュ

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Abstract

A 51-year-old man visited our hospital because of fever in 2003. With the discovery of the presence of a chest wall tumor, pleural effusion and M-protein, and increased plasma cells in the bone marrow, a diagnosis of multiple myeloma was established. Since the effect of combination chemotherapy followed by tandem auto-PBSCT lasted only one year, thalidomide and dexamethasone administration was started in November 2004. However, three months later, his lower limbs became swollen. Elevation of fibrin degradation product (FDP) and computed tomography findings suggested deep vein thrombosis and pulmonary embolism. With heparin and warfarin, these thromboses disappeared. Furthermore, chemotherapy strategies in addition to thalidomide were safely performed with anti-coagulation therapy. As thalidomide has become an accepted component in therapeutic strategies for multiple myeloma, careful attention must be paid to the prevention of thrombosis.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 47 (7), 656-660, 2006

    The Japanese Society of Hematology

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