Fluvastatin Alters Psychomotor Performance and Daily Activity but not the Spatial Memory in Rats

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著者

    • ALKANAT MEHMET
    • Department of Physiology, Karadeniz Technical University, Medical School
    • OZEREN MEHMET
    • Department of Obstetrics and Gynecology, Karadeniz Technical University, Medical School
    • EKINCI MURAT
    • Department of Computer Engineering, Engineering School, Karadeniz Technical University
    • AKGUN AHMET
    • Department of Physiology, Karadeniz Technical University, Medical School

抄録

Statins, inhibitors of cholesterol synthesis for treating dyslipidemia and preventing cardiovascular complications, have been shown to alter central nervous system functions. Our aim was to investigate the effects of the fluvastatin, a member of statin family, on psychomotor performance, daily activity and spatial memory. Sprague-Dawley rats were treated with fluvastatin (<i>n</i> = 8) or placebo as a control (<i>n</i> = 11) regardless of sex. Fluvastatin (7.5 mg/kg) was administered orally once a day for four weeks, while the control group was administered only placebo. Psychomotor performance was measured by rotarod tests. No significant difference was observed in the fluvastatin group over the course of weeks, but the control group preferred to stay on the device shorter times (<i>p</i> < 0.05). For the first three weeks of the drug administration there was a statistical difference between the groups, however no difference was found after the 4th week. There was no difference in the Barnes maze spatial memory test between the groups and also within the groups over the course of time. Daily activity tests revealed that stereotypical and vertical movements of the fluvastatin group were significantly less than the control group in all four weeks. Ambulatory movements and the distances taken by the fluvastatin group were decreased significantly over the course of time (<i>p</i> < 0.005 and <i>p</i> < 0.001, respectively), but the control group did not reveal any significant change. Our results suggest that fluvastatin altered psychomotor performance and daily activity in rats, but it did not affect the spatial memory. These behavioral changes might be associated with alterations in the composition of the brain lipids caused by fluvastatin.

収録刊行物

  • THE TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE  

    THE TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 209(4), 311-320, 2006-08-01 

    Tohoku University Medical Press

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各種コード

  • NII論文ID(NAID)
    10018172206
  • NII書誌ID(NCID)
    AA00863920
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00408727
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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