Severe Hypothyroidism Induced by Thyroid Metastasis of Colon Adenocarcinoma: A Case Report and Review of the Literature

• YOUN Jong Chan

  Department of Internal Medicine, College of Medicine, Yonsei University

• RHEE Yumie

  Department of Internal Medicine, College of Medicine, Yonsei University

• PARK Soo Young

  Department of Internal Medicine, College of Medicine, Yonsei University

• KIM Won Ho

  Department of Internal Medicine, College of Medicine, Yonsei University

• KIM Soo Jung

  Department of Internal Medicine, College of Medicine, Yonsei University

• CHUNG Hyun Cheol

  Department of Internal Medicine, College of Medicine, Yonsei University

• HONG Soon Won

  Department of Pathology, College of Medicine, Yonsei University

• LIM Sung-Kil

  Department of Internal Medicine, College of Medicine, Yonsei University

抄録

An 85-year-old man who had undergone a right hemicolectomy for colon cancer presented with severe hypothyroidism and hoarseness 21 months after the operation. The serum thyrotropin (TSH) was markedly elevated to 118.14 μIU/mL and serum free thyroxine (fT4) level was markedly suppressed to 0.34 ng/dL. Symptoms of hoarseness and neck swelling were already evident 4 months prior at which time tests for normal thyroid function were performed. The patient was referred due to aggravated pain on his diffusely enlarged hard goiter. An enlarged thyroid with some calcification was noticed in the neck ultrasonography with multiple cervical lymphadenopathies. Core biopsy of the thyroid gland showed invasion of poorly differentiated adenocarcinoma cells. Immunohistochemical studies showed positive staining only for carcinoembryonic antigen (CEA). There were multiple lung parenchymal nodules and adrenal masses at the time of evaluation. The patient was started on palliative chemotherapy with thyroid hormone replacement and gradually became euthyroid. From these findings and the clinical observations, thyroid metastasis with hypothyroidism developing acutely from metastatic colon adenocarcinoma was diagnosed.<br>

収録刊行物

• Endocrine Journal

  Endocrine Journal 53 (3), 339-343, 2006

  一般社団法人 日本内分泌学会

キーワード

• Hypothyroidism
• Metastatic thyroid cancer
• Colon adenocarcinoma
• Immunohistochemical staining
• Diagnosis

詳細情報

• CRID: 1390001206297357696
• NII論文ID: 10018177987
• NII論文ID: 130004443229
• NII書誌ID: AA10901436
• DOI: 10.1507/endocrj.k05-115
• ISSN: 13484540
• ISSN: 09188959
• Web Site: http://www.jstage.jst.go.jp/article/endocrj/53/3/53_3_339/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2007068923
• 本文言語コード: en
• データソース種別:
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  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可