A Case of Hepatitis C-Associated Osteosclerosis in an Elderly Japanese Man
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- TANAKA Tokuji
- Division of Endocrinology and Metabolism, Osaka Red Cross Hospital
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- OKI Shogo
- Division of Endocrinology and Metabolism, Osaka Red Cross Hospital
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- MURO Seiji
- Division of Endocrinology and Metabolism, Osaka Red Cross Hospital
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- TANAKA Kiyoshi
- Department of Food and Nutrition, Kyoto women's University
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- HASHIMOTO Jun
- Department of Orthopedic Surgery, Osaka University
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抄録
Hepatitis C-Associated Osteosclerosis (HCAO) is characterized by a marked increase in bone mass with deep bone pain. Since 1992, eleven cases of HCAO have been reported. This report describes an elderly Japanese man with HCAO, whose clinical course we followed for 3 years. A 68-year-old man developed pain in both pretibial regions in June 2000, and he had frequent episodic loss of muscular strength in his hands. He had recieved blood transfusion for a bleeding ulcer 43 years before and was seropositive for hepatitis C virus. His serum alkaline phosphatase (ALP) level was markedly increased, while his serum calcium was slightly decreased and serum phosphate was normal. Skeletal radiographs of the lower extremities showed a progressive increase in skeletal density, but did not show any apparent deformity. Administration of nonsteroidal anti-inflammatory drugs led to a reduction in bone pain. Treatment with vitamin D3 and calcium decreased the number of episodes of sudden muscular weakness and maintained serum calcium within the normal range. Three years after the onset of the disease, bone mineral density of his lumbar vertebrae and left hip rose from 0.963 g/cm2 to 1.096 g/cm2, and from 0.938 g/cm2 to 1.383 g/cm2, respectively. His serum ALP level decreased from 2889 to 277 IU/L (normal range: 104-338) and serum calcium normalized. These findings were accompanied by a decrease in bone pain. This case and previous reports suggest that the skeletal tissue of this disease appears to be of good quality. <br>
収録刊行物
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- Endocrine Journal
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Endocrine Journal 53 (3), 393-399, 2006
一般社団法人 日本内分泌学会
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詳細情報 詳細情報について
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- CRID
- 1390001206297385216
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- NII論文ID
- 10018178166
- 130004443236
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- NII書誌ID
- AA10901436
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- ISSN
- 13484540
- 09188959
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
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- 使用不可