Pharmaceutical Industrial Experiments on Continuous Cryogenic Reactions Using Mini-Sized Multi-Stage Reactors

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The pharmaceutical industry frequently uses cryogenic conditions for organometallic reactions and for the stereoselective synthesis of active pharmaceutical ingredients. Cryogenic conditions are required for these reactions either because of the thermal instability of the organometallic compound, or in order to improve the selectivity of the reaction. This paper focuses on continuous cryogenic organic reactions using mini-sized multi-stage reactors with volumes ranging from 10<SUP>–6</SUP> to 10<SUP>–3</SUP> m<SUP>3</SUP>. Mini-sized reactors have many advantages, such as high heat exchange, and efficient and fast mixing comparable to micro-scale reactors. However, mini-sized reactors are easier to operate than micro-scale reactors. The present study deals with synthesis of spirolactone fragment of neuropeptide Y receptor antagonist which is a potential anti-obesity agent. Currently, production is carried out in a semi-batch manner. Due to limitations in heat transfer, temperature control is maintained by slow addition of reactants, although this leads to poor product yield, especially in the second step of the process. The present results, obtained using a mini-sized multi-stage reactor, are compared with the current production scale approach in terms of the product yield, the amount of by-products and the stereoselectivity of the product.

収録刊行物

  • Journal of chemical engineering of Japan  

    Journal of chemical engineering of Japan 39(7), 772-776, 2006-07-01 

    公益社団法人 化学工学会

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各種コード

  • NII論文ID(NAID)
    10018182871
  • NII書誌ID(NCID)
    AA00709658
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00219592
  • NDL 記事登録ID
    7987480
  • NDL 雑誌分類
    ZP1(科学技術--化学・化学工業)
  • NDL 請求記号
    Z53-R395
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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