Amination of the Ortho C-H Bonds by the Cu(OAc)_2-mediated Reaction of 2-Phenylpyridines with Anilines
The reaction of 2-phenylpyridines with anilines in the presence of Cu(OAc)<SUB>2</SUB> as a promoter results in selective mono-amination of the ortho C–H bonds in 2-phenylpyridines to give amine derivatives in high yields per the conversion. This is the rare example of the functionalization of C–H bonds to C–N bonds.
- Chemistry letters
Chemistry letters 35(8), 842-843, 2006-08-05
The Chemical Society of Japan