Successful Treatment of Invasive Sinus Aspergillosis with Micafungin and Itraconazole
-
- OKAMOTO Masaki
- Comprehensive Care and Education, Tenri Hospital
-
- AZUMA Teruhisa
- Comprehensive Care and Education, Tenri Hospital
-
- ISHIMARU Hiroyasu
- Comprehensive Care and Education, Tenri Hospital
-
- ABE Noriyuki
- Department of Clinical Patholog, Tenri Hospital
-
- KOMATSU Masaru
- Department of Clinical Patholog, Tenri Hospital
-
- HATTA Kazuhiro
- Comprehensive Care and Education, Tenri Hospital
Bibliographic Information
- Other Title
-
- ミカファンギン, イトラコナゾールの併用投与が有効であった侵襲性副鼻腔アスペルギルス症の1例
- 症例 ミカファンギン,イトラコナゾールの併用投与が有効であった侵襲性副鼻腔アスペルギルス症の1例
- ショウレイ ミカファンギン イトラコナゾール ノ ヘイヨウ トウヨ ガ ユウコウ デ アッタ シンシュウセイ フクビクウ アスペルギルスショウ ノ 1レイ
- Successful treatment of invasive sinus aspergillosis with micafungin and itraconazole (in Japanese)
Search this article
Abstract
We report a case of invasive sinus aspergillosis that extended to the orbital cavity and cavernous sinus and was improved by treatment with micafungin and itraconazole.<BR>Case report. A 83-year-old woman was referred to our hospital because of headache and impaired of eye movement on the right side. Physical examination revealed impaired function of cranial nerves, II, III, IV, and VI on the right side.<BR>MRI showed evidence of inflammation of the right sphenoid sinus and ethmoidal sinus and an enhancing mass in the right cavernous sinus and orbit. Because a culture of a specimen from the right sphenoid sinus extracted during endoscopic sinus surgery, yieledeAspergillus fumigatus, a diagnosed of invasive sinus aspergillosis complicated by cavernous sinus symdrome and orbital apex symdrome was made. It was difficult to completely remove the mass in the sinuses surgically and drug therapy with micafungin was started and then itraconazole was added. The clinical manifestations and the impaired function of cranial nerves II, III, IV, and VI improved, and MRI showed regression of the mass in the sinuses temporary in response to drug therapy.<BR>Conclusion. Invasive sinus aspergillosis often progresses rapidly in the absence of surgery. Our case is valuable, because invasive sinus aspergillosis was improved by drug therapy alone, and combined treatment with micafungin and itraconazole was effective.
Journal
-
- Kansenshogaku Zasshi
-
Kansenshogaku Zasshi 80 (2), 115-118, 2006
The Japanese Association for Infectious Diseases
- Tweet
Details 詳細情報について
-
- CRID
- 1390001205048661120
-
- NII Article ID
- 10018193266
- 130004331300
-
- NII Book ID
- AN00047715
-
- COI
- 1:STN:280:DC%2BD283it1SqtA%3D%3D
-
- ISSN
- 1884569X
- 03875911
- http://id.crossref.org/issn/03875911
-
- NDL BIB ID
- 7916573
-
- PubMed
- 16629496
-
- Data Source
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- Abstract License Flag
- Disallowed