PREOPERATIVE COMBINED MODALITY THERAPY IN PATIENT WITH INOPERABLE SIGMOID COLON CANCER-CASE REPORT-

  • OKUGAWA Yoshinaga
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine Institute of Life Science Mie University Graduate School of Medicine
  • INOUE Yasuhiro
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine Institute of Life Science Mie University Graduate School of Medicine
  • OJIMA Hideki
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine Institute of Life Science Mie University Graduate School of Medicine
  • KOBAYASHI Minako
    Department of Innovative Surgery and Surgical Techniques Development, Division of Reparative Medicine Institute of Life Science Mie University Graduate School of Medicine
  • MIKI Chikao
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine Institute of Life Science Mie University Graduate School of Medicine
  • KUSUNOKI Masato
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine Institute of Life Science Mie University Graduate School of Medicine

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Other Title
  • 切除不能S状結腸癌に対し集学的治療が奏効した1例

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Abstract

The case was a 53-year-old man who was admitted for a bladder tumor with hematuria. He was diagnosed with unresectable sigmoid colon cancer together with bladder and pelvic wall invasion. After diversion transverse colostomy, he was treated by neoadjuvant chemoradiation therapy. Radiation therapy was delivered with total pelvic dose of 45 Gy together with pharmacokinetic modulating chemotherapy (tegafur-uracil 400mg/day×7 days, and 5-FU 600mg/m2/24 hr iv/week). The tumor was decreased significantly in size after that course, and subtotal colectomy and diversion ascending colostomy were then performed. The postoperative course was satisfactory, and now he is disease-free 8 months after operation. For the patient with inoperable primary colorectal cancer without evidence of distant metastases, combined modality therapy for improvement of respectability would improve the prognosis.

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