Predictive factors for intrahepatic distant recurrence of hepatocellular carcinoma after radiofrequency ablation for primary tumors

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  • Hikita Hayato
    Department of gastroenterology and hepatology, National Hospital Organization Osaka Minami Medical Center
  • Tanaka Yoshio
    Department of gastroenterology and hepatology, National Hospital Organization Osaka Minami Medical Center
  • Shigekawa Minoru
    Department of gastroenterology and hepatology, National Hospital Organization Osaka Minami Medical Center
  • Mukai Kaori
    Department of gastroenterology and hepatology, National Hospital Organization Osaka Minami Medical Center
  • Nakamura Keiko
    Department of gastroenterology and hepatology, National Hospital Organization Osaka Minami Medical Center
  • Song Changho
    Department of gastroenterology and hepatology, National Hospital Organization Osaka Minami Medical Center
  • Tatsumi Osamu
    Department of gastroenterology and hepatology, National Hospital Organization Osaka Minami Medical Center
  • Inoue Yuko
    Department of gastroenterology and hepatology, National Hospital Organization Osaka Minami Medical Center
  • Sasakawa Akira
    Department of gastroenterology and hepatology, National Hospital Organization Osaka Minami Medical Center
  • Nakanishi Fumihiko
    Department of gastroenterology and hepatology, National Hospital Organization Osaka Minami Medical Center
  • Masuda Eiji
    Department of gastroenterology and hepatology, National Hospital Organization Osaka Minami Medical Center
  • Hijioka Taizo
    Department of gastroenterology and hepatology, National Hospital Organization Osaka Minami Medical Center

Bibliographic Information

Other Title
  • 初発肝細胞癌に対するラジオ波焼灼療法後の異所再発に関する予測因子の検討
  • ショハツ カン サイボウガン ニ タイスル ラジオハ ショウシャク リョウホウ ゴ ノ イショ サイハツ ニ カンスル ヨソク インシ ノ ケントウ

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Abstract

We studied 56 patients with primary hepatocellular carcinoma (HCC) treated with radiofrequency ablation (RFA) in our hospital to clarify the predictive factors for intrahepatic distant recurrence. The observation period was 16.4 months. Cumulative rate of recurrence was 12.0% in a year and 53.5% in 3 years. Multivariate analysis revealed that multinodular HCC (odds ratio 4.78, p=0.01) and platelet count <10.0×104/μl (odds ratio 5.25, p<0.01) were considered to be useful predictive factors for recurrence. These recurrence rate and factors after RFA were similar to those after surgical resection. Therefore, patients showed uninodular HCC and whose platelet count was 10.0×104/μl and over before treatment might not be treated with RFA, but surgical resection if possible. However, considering remnant liver function and recurrence rate, we think patients either showed multinodular HCC or whose platelet count was less than 10.0×104/μl before treatment should be treated with RFA if possible.<br>

Journal

  • Kanzo

    Kanzo 47 (4), 209-216, 2006

    The Japan Society of Hepatology

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