Further evidence for recombination between mouse hemoglobin beta b1 and b2 genes based on the nucleotide sequences of intron, UTR, and intergenic spacer regions

この論文にアクセスする

この論文をさがす

著者

抄録

Nucleotide sequences of the intron regions and UTRs (Untranslated regions) of the hemoglobin beta adult genes, b1 and b2, and of the intergenic spacer region were determined for mouse strains representing the <i>d</i>, <i>p</i>, and <i>w1</i> hemoglobin haplotypes defined by protein electrophoretic analyses. The hypothesis of recombination of the b1 and b2 genes between the <i>d</i> and <i>w1</i> haplotypes previously reported in the cDNA nucleotide sequences was confirmed by neighbor-joining analyses of the intron regions and UTRs within the b1 and b2 genes, suggesting that all of the structures of hemoglobin beta adult genes support the hypothesis that the <i>p</i> haplotype was established by hybridization between <i>d</i> and <i>w1</i> haplotype mice. The resultant recombinant of the <i>p</i> haplotype was found to have a <i>d</i>-like b1 gene and a <i>w1</i>-like b2 gene. In addition to the possible recombination, a break point was suggested around 2–3 kb downstream of the b1 gene within the intergenic spacer region, despite the absence of clear properties that could stimulate the recombination machinery. Some large insertions or deletions (indels) specific to the <i>p</i> or <i>d</i> haplotypes were located within the intergenic spacer region, in which the 1010-bp indel specific to the <i>p</i> haplotype was shared by all examined strains representing the <i>p</i> haplotype.<br>

収録刊行物

  • Genes & genetic systems  

    Genes & genetic systems 81(3), 201-209, 2006-06-25 

    The Genetics Society of Japan

参考文献:  36件

参考文献を見るにはログインが必要です。ユーザIDをお持ちでない方は新規登録してください。

各種コード

  • NII論文ID(NAID)
    10018212763
  • NII書誌ID(NCID)
    AA11077421
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13417568
  • NDL 記事登録ID
    7997993
  • NDL 雑誌分類
    ZR1(科学技術--生物学)
  • NDL 請求記号
    Z53-W539
  • データ提供元
    CJP書誌  NDL  J-STAGE 
ページトップへ