Further evidence for recombination between mouse hemoglobin beta b1 and b2 genes based on the nucleotide sequences of intron, UTR, and intergenic spacer regions
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- Sato Jun J.
- Laboratory of Animal Cell Technology, Faculty of Life Science and Technology, Fukuyama University
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- Tsuru Yoshiharu
- Laboratory of Animal Cell Technology, Faculty of Life Science and Technology, Fukuyama University
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- Hirai Kyoko
- Laboratory of Animal Cell Technology, Faculty of Life Science and Technology, Fukuyama University
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- Yamaguchi Yasunori
- Laboratory of Animal Cell Technology, Faculty of Life Science and Technology, Fukuyama University
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- Mekada Kazuyuki
- RIKEN Tsukuba Institute, RIKEN Bioresource Center
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- Takahata Naoyuki
- Department of Biosystems Science, Graduate University for Advanced Studies
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- Moriwaki Kazuo
- RIKEN Tsukuba Institute, RIKEN Bioresource Center
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抄録
Nucleotide sequences of the intron regions and UTRs (Untranslated regions) of the hemoglobin beta adult genes, b1 and b2, and of the intergenic spacer region were determined for mouse strains representing the d, p, and w1 hemoglobin haplotypes defined by protein electrophoretic analyses. The hypothesis of recombination of the b1 and b2 genes between the d and w1 haplotypes previously reported in the cDNA nucleotide sequences was confirmed by neighbor-joining analyses of the intron regions and UTRs within the b1 and b2 genes, suggesting that all of the structures of hemoglobin beta adult genes support the hypothesis that the p haplotype was established by hybridization between d and w1 haplotype mice. The resultant recombinant of the p haplotype was found to have a d-like b1 gene and a w1-like b2 gene. In addition to the possible recombination, a break point was suggested around 2–3 kb downstream of the b1 gene within the intergenic spacer region, despite the absence of clear properties that could stimulate the recombination machinery. Some large insertions or deletions (indels) specific to the p or d haplotypes were located within the intergenic spacer region, in which the 1010-bp indel specific to the p haplotype was shared by all examined strains representing the p haplotype.<br>
収録刊行物
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- Genes & Genetic Systems
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Genes & Genetic Systems 81 (3), 201-209, 2006
日本遺伝学会
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詳細情報 詳細情報について
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- CRID
- 1390282680449541248
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- NII論文ID
- 10018212763
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- NII書誌ID
- AA11077421
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- ISSN
- 18805779
- 13417568
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- NDL書誌ID
- 7997993
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可