臓器移植における深在性真菌症 [in Japanese] Prophylaxis and Treatment for Invasive Fungal Infections in Solid Organ Transplant Recipients [in Japanese]
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臓器移植領域における深在性真菌症は, 発生頻度は低くても治療は容易でなく, とくにアスペルギルス症は依然として死亡率が高い. 移植領域では抗真菌薬の予防投与・先制攻撃的治療・経験的治療が重要視されるが, その基準は必ずしも明確ではない. 新規抗真菌薬の登場もふまえて, 今後, 薬剤の位置づけと選択方法が示されていくであろう.
Solid organ transplantation is becoming increasingly common in Japan. Despite invasive fungal infections being less common than bacterial and viral infections, fungal infections still result in a higher mortality rate. Empiric and pre-emptive therapy plays an important role in management of invasive fungal infections, because successful treatment is difficult after a definite diagnosis of an invasive disease, especially invasive aspergillosis. Given this situation, to improve outcome, high risk patients need to be identified and antifungal prophylaxis is mandatory in preventing the development of the disease. However, antifungal prophylaxis for solid organ transplant recipients remains controversial. New antifungal agents might change the choice of fungal prevention and treatment.
- Japanese Journal of Medical Mycology
Japanese Journal of Medical Mycology 47(3), 167-169, 2006-07-31
The Japanese Society for Medical Mycology