Contribution of Dectin-1 to the Recognition of Fungal Cell Wall Products and the Activation of Innate Immune Response

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  • Adachi Yoshiyuki
    Laboratory for Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Science
  • Ohno Naohito
    Laboratory for Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Science

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  • 真菌多糖の免疫系による認識とその活性化作用
  • シンキン タトウ ノ メンエキケイ ニ ヨル ニンシキ ト ソノ カッセイカ サヨウ

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Abstract

1,3-β-glucans is a major cell wall component in fungi. Receptor molecules relating to innate immunity may recognize such cell wall products, and affect host defense systems. A β-glucan receptor, dectin-1, is a C-type lectin and may contribute to the innate immune responses. To examine the role of dectin-1 in recognition of 1,3-β-glucans and subsequent activation of intracellular signaling, the molecular characteristics of a carbohydrate recognition domain (CRD) of dectin-1 were investigated. The binding ability to β-glucans was abolished by mutating two amino acid residues, Trp221 and His223, on the CRD. Dectin-1 increased TLR2-mediated NF-κB activation in response to zymosan. However, dectin-1 alone could not affect the activation pathway for NF-κB, nor did co-expression of dectin-1 mutant and TLR2 increase the NF-κB activation. These results suggest that dectin-1 may have a co-stimulatory effect on leukocyte activation in response to fungal infection.

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