A Senescent Patient with Ethomoidal Embryonal Rhabdomyosarcoma Showed Positive Staining for c-kit.
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- Ishii Kenji
- Department of Otolaryngology, Hirosaki University School of Medicine
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- Ota Shuji
- Department of Otolaryngology, Aomori Prefectural Central Hospital
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- Sariishi Takumi
- Department of Otolaryngology, Hirosaki University School of Medicine
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- Abe Takahisa
- Department of Otolaryngology, Hirosaki University School of Medicine
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- Shirasaki Riki
- Department of Otolaryngology, Hirosaki University School of Medicine
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- Shinkawa Hideichi
- Department of Otolaryngology, Hirosaki University School of Medicine
Bibliographic Information
- Other Title
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- 高齢者の篩骨洞に原発した c-kit 陽性を示した胎児型横紋筋肉腫の1例
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Abstract
We report a case of embryonal rhabdomyosarcoma originating in the right ethmoidal sinus. A 68-year old man reporting right cheek swelling and epiphora for 2 months was found in computed tomography to have a tumor in the right ethmoidal sinus and bilateral neck lymph nodes metastasis. Bone scintigraphy showed metastasis to the ribs. We treated him with irradiation and chemotherapy. The chemotherapy protocol was CYVADIC (cyclophosphamide, vincristine, adriamycin, dacarbazine). He underwent chemotherapy 5 times but the tumor was not controlled. Imatinib mesilate (Glivec®) is a new drug targeting mutations of the c-kit gene that can have therapeutic effects in gastrointestinal stromal tumors and leukemia. We tried imatinib mesilate because the tumor showed positive staining for c-kit. The drug was not effective, but gene-targeting drugs such as imatinib mesilate may be useful for patients with malignant tumors because there are many such c-kit positive tumors.
Journal
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- Nihon Bika Gakkai Kaishi (Japanese Journal of Rhinology)
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Nihon Bika Gakkai Kaishi (Japanese Journal of Rhinology) 45 (2), 133-137, 2006
Japan Rhinologic Society
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Details 詳細情報について
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- CRID
- 1390282679713530880
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- NII Article ID
- 130003873813
- 10018227641
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- NII Book ID
- AN00062865
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- ISSN
- 18837077
- 09109153
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed