Proteomic Modification by Nitric Oxide

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著者

    • Bian Ka BIAN Ka
    • The Institute of Molecular Medicine, The University of Texas-Houston Medical School
    • Ke Yan KE Yan
    • The Murad Research Institute for Modernized Chinese Medicine and Shanghai University of Traditional Chinese Medicine
    • MURAD Ferid
    • The Institute of Molecular Medicine, The University of Texas-Houston Medical School

抄録

The role of nitric oxide (NO) in cellular signaling has become one of the most rapidly growing areas in biology during the past two decades. As a gas and free radical with an unshared electron, nitric oxide participates in various biological processes. The interaction between NO and proteins may be roughly divided into two categories. In many instances, NO mediates its biological effects by activating guanylyl cyclase and elevates intracellular cyclic GMP synthesis from GTP. However, the list of cGMP-independent effects of NO is also growing at a rapid rate. In this review, the importance and relevance of nitrotyrosine formation are stressed. The utilization of intact cell cultures, tissues, and cell-free preparations along with the use of pharmacological, biochemical, and molecular biological approaches to characterize, purify, and reconstitute these NO regulatory pathways could lead to the development of new therapies for various pathological conditions that are characterized by unbalanced production of NO.<br>

収録刊行物

  • Journal of pharmacological sciences  

    Journal of pharmacological sciences 101(4), 271-279, 2006-08-20 

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10018236310
  • NII書誌ID(NCID)
    AA11806667
  • 本文言語コード
    ENG
  • 資料種別
    REV
  • ISSN
    13478613
  • NDL 記事登録ID
    8022954
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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