Effects of Subchronic Treatment With Selegiline on <sc>L</sc>-DOPA-Induced Increase in Extracellular Dopamine Level in Rat Striatum
-
- Adachi Kouichi
- Department of Neurology, Wakayama Medical University, Japan
-
- Miwa Hideto
- Department of Neurology, Wakayama Medical University, Japan
-
- Kusumoto Haruko
- Research Institute, Fujimoto Pharmaceutical Corporation, Japan
-
- Shimazu Seiichiro
- Research Institute, Fujimoto Pharmaceutical Corporation, Japan
-
- Kondo Tomoyoshi
- Department of Neurology, Wakayama Medical University, Japan
Bibliographic Information
- Other Title
-
- Effects of Subchronic Treatment With Selegiline on L-DOPA-Induced Increase in Extracellular Dopamine Level in Rat Striatum
Search this article
Abstract
Selegiline is used an adjunct to <sc>L</sc>-DOPA therapy. We investigated extracellular striatal dopamine (DA) level in awake rats treated with <sc>L</sc>-DOPA and/or selegiline using a microdialysis method. Rats given 10 mg/kg, i.p. per day selegiline for 7 days were administered with a single dose of 100 mg/kg, i.p. <sc>L</sc>-DOPA 0 (3 h), 1, 3, 7, 14, 21, or 28 days after the last selegiline treatment. Carbidopa was administered 0.5 h before <sc>L</sc>-DOPA administration. The significant increase in basal DA level before <sc>L</sc>-DOPA treatment persisted until 1 day after the last selegiline treatment, and the significant decrease in basal DOPAC level persisted for more than 28 days. Thus, selegiline affected DA catabolism for more than 28 days. Total monoamine oxidase (MAO) and MAO-B activities at day 0 decreased by 22% and 5.7%, respectively. The significant enhancement of <sc>L</sc>-DOPA-induced increase in DA level was observed until 3 days after the last selegiline treatment. Next, the effects of reducing <sc>L</sc>-DOPA dose by 25% were examined 3 h after the last selegiline treatment. A dose-dependent decrease in DA level was observed, indicating that DA level in selegiline-treated rats can be controlled by <sc>L</sc>-DOPA dose.<br>
Journal
-
- Journal of Pharmacological Sciences
-
Journal of Pharmacological Sciences 101 (4), 286-292, 2006
The Japanese Pharmacological Society
- Tweet
Keywords
Details 詳細情報について
-
- CRID
- 1390282680154416896
-
- NII Article ID
- 10018236415
- 130000074472
-
- NII Book ID
- AA11806667
-
- ISSN
- 13478648
- 13478613
-
- NDL BIB ID
- 8022996
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- Abstract License Flag
- Disallowed