Recent Advances in Molecular Pharmacology of the Histamine Systems : Immune Regulatory Roles of Histamine Produced by Leukocytes

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Accumulating evidence has highlighted the importance of histamine in immune responses. The H<sub>1</sub> receptor is involved not only in allergic inflammatory reactions but also in augmentation of helper T cell (Th)1 responses, whereas H<sub>2</sub> receptor suppresses Th responses and participates in immune tolerance through interleukin-10 and transforming growth factor-β. Identification of the H<sub>4</sub> receptor, which binds to histamine with high affinity and of which expression is limited to the hematopoietic system, has enhanced the importance of histamine in immune responses. However, since a majority of previous studies has evaluated the effects of exogenous histamine, it remains largely unknown how endogenously produced histamine is involved in regulation of such kinds of immune responses. Insight into precise roles of histamine in the immune system can not be obtained without correct understanding of both the predominance of a certain type of histamine receptor and the regulation of histamine synthesis. Here we review a part of the recent progress in histamine research in the field of immunology with attention to the source of involved histamine.<br>

収録刊行物

  • Journal of pharmacological sciences  

    Journal of pharmacological sciences 101(1), 19-23, 2006-05-20 

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10018237193
  • NII書誌ID(NCID)
    AA11806667
  • 本文言語コード
    ENG
  • 資料種別
    REV
  • ISSN
    13478613
  • NDL 記事登録ID
    7915667
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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