The Antioxidative Effects of Astragalus Saponin I Protect Against Development of Early Diabetic Nephropathy

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It has been known that oxidative stress plays an important role in the development of diabetic nephropathy (DN). The antioxidative effects of <i>Astragalus</i> saponin I (AS I) were studied in vitro and in vivo. In the presence of high glucose and H<sub>2</sub>O<sub>2</sub>, the total antioxidative capability, catalase, reduced glutathione, and superoxide dismutase level of rat mesangial cells were significantly decreased, and transforming growth factor β1 (TGF-β1) mRNA level, collagen IV, and laminin level were significantly increased. When compared with those in the high glucose group, these 4 indexes of cells incubated in 2.0 and/or 20 μmol/L of AS I were significantly enhanced, and levels of TGF-β1 mRNA, collagen IV and laminin were statistically decreased. By flowcytomery, percentages of S phase of cells incubated in high glucose and H<sub>2</sub>O<sub>2</sub> were lowered, while those in AS I were increased. Furthermore, the physical behaviors of rats treated with 12 mg/kg of AS I restored with vigor and weight gaining, while the level of HbAlC was significantly reduced. Thus, AS I has antioxidative effects and is a potential compound worth further study because it may prevent the development of DN.<br>

収録刊行物

  • Journal of pharmacological sciences  

    Journal of pharmacological sciences 101(2), 166-173, 2006-06-20 

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10018237881
  • NII書誌ID(NCID)
    AA11806667
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13478613
  • NDL 記事登録ID
    7963408
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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