Extracellular-Added ADP-Ribose Increases Intracellular Free Ca^<2+> Concentration Through Ca^<2+> Release From Stores, but Not Through TRPM2-Mediated Ca^<2+> Entry, in Rat β-Cell Line RIN-5F

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Intracellular ADP-ribose is an activator of TRPM2, which is a Ca<sup>2+</sup>-permeable channel and mediates H<sub>2</sub>O<sub>2</sub>-induced cell death, in the TRPM2-expressing rat β-cell line RIN-5F. We examined the effect of extracellular-added ADP-ribose on intracellular Ca<sup>2+</sup> concentration in RIN-5F cells. ADP-ribose induced Ca<sup>2+</sup> release from the thapsigargin-sensitive Ca<sup>2+</sup> store, but not Ca<sup>2+</sup> entry across the plasma membrane. A phospholipase C (PLC) inhibitor and a non-specific IP<sub>3</sub> receptor inhibitor blocked its Ca<sup>2+</sup> release. H<sub>2</sub>O<sub>2</sub>-induced Ca<sup>2+</sup> entry through TRPM2 was not affected by extracellular ADP-ribose. These findings suggest that extracellular-added ADP-ribose induces Ca<sup>2+</sup> release through the PLC-IP<sub>3</sub> pathway and does not act as a TRPM2 activator.<br>

収録刊行物

  • Journal of pharmacological sciences  

    Journal of pharmacological sciences 101(2), 174-178, 2006-06-20 

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10018237910
  • NII書誌ID(NCID)
    AA11806667
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    13478613
  • NDL 記事登録ID
    7963437
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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