Calcium Ion as a Second Messenger With Special Reference to Excitation-Contraction Coupling

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Calcium ion (Ca<sup>2+</sup>) plays an important role in stimulus-response reactions of cells as a second messenger. This is done by keeping cytoplasmic Ca<sup>2+</sup> concentration low at rest and by mobilizing Ca<sup>2+</sup> in response to stimulus, which in turn activates the cellular reaction. The role of Ca<sup>2+</sup> as a second messenger was first discovered in excitation-contraction coupling of skeletal muscle. The history of the discovery was reviewed. Characteristics of Ca<sup>2+</sup> as a second messenger, diversity of target molecules, capability of rapid and massive mobilization and also of oscillatory mobilization, tendency toward localization, and on the other side, ability to cause generalized cell response were described. The possible bases for these characteristics was discussed. Ca<sup>2+</sup> itself induces release of Ca<sup>2+</sup> from the sarcoplasmic reticulum (Ca<sup>2+</sup>-induced Ca<sup>2+</sup> release [CICR]). The Ca<sup>2+</sup> release channel, ryanodine receptor, incorporated into lipid bilayer shows CICR activity. Ca<sup>2+</sup> release induced by inositol trisphosphate also has an apparent CICR nature. The significance of CICR or apparent CICR with its inherently regenerative nature in physiological contractions of skeletal, cardiac, and smooth muscles was discussed.<br>

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  • Journal of pharmacological sciences  

    Journal of pharmacological sciences 100(5), 519-524, 2006-05-15 

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10018239506
  • NII書誌ID(NCID)
    AA11806667
  • 本文言語コード
    ENG
  • 資料種別
    REV
  • ISSN
    13478613
  • NDL 記事登録ID
    7963290
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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