Ca^<2+>-Dependent Inositol 1,4,5-Trisphosphate and Nitric Oxide Signaling in Cerebellar Neurons

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Intracellular Ca<sup>2+</sup> signals are important for the regulation of synaptic functions in the central nervous system. In this review, I summarize findings of our recent studies on upstream and downstream Ca<sup>2+</sup> signaling mechanisms in cerebellar synapses using novel molecular imaging methods. Inositol 1,4,5-trisphosphate (IP<sub>3</sub>)-induced Ca<sup>2+</sup> release plays a pivotal role in central synapses. The visualization of IP<sub>3</sub> at fine dendrites of Purkinje cells (PCs) using a fluorescent IP<sub>3</sub> indicator showed that intracellular Ca<sup>2+</sup> concentration has a stimulatory effect on phospholipase C activity, which catalyzes IP<sub>3</sub> production. This indicates that metabotropic and ionotropic glutamate receptors collaborate to generate IP<sub>3</sub> signals. Using a novel nitric oxide (NO) indicator, the spatial distribution of NO signals originating from parallel fiber (PF) terminals was visualized. Our results show that the NO signal decays steeply with distance from the site of production in the cerebellum and is dependent on PF stimulation frequency in a biphasic manner. NO released from PF terminals generated a synapse-specific long-term potentiation of PF-PC synapse when PF was stimulated at certain frequencies. These imaging studies clarified new aspects of the regulatory mechanisms of synaptic functions.<br>

収録刊行物

  • Journal of pharmacological sciences  

    Journal of pharmacological sciences 100(5), 538-544, 2006-05-15 

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10018239654
  • NII書誌ID(NCID)
    AA11806667
  • 本文言語コード
    ENG
  • 資料種別
    REV
  • ISSN
    13478613
  • NDL 記事登録ID
    7963308
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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