Calcium Signals for Egg Activation in Mammals

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A dramatic increase in intracellular Ca<sup>2+</sup> concentration ([Ca<sup>2+</sup>]<sub>i</sub>) occurs in eggs at fertilization common to all animal species examined to date, and this serves as a pivotal signal for egg activation characterized by resumption of meiotic cell division and formation of the pronuclei. In mammalian eggs, repetitive [Ca<sup>2+</sup>]<sub>i</sub> rises (Ca<sup>2+</sup> oscillations) each of which accompanies a propagating wave across the egg occur due to release of Ca<sup>2+</sup> from the endoplasmic reticulum mainly through type 1 inositol 1,4,5-trisphosphate (IP<sub>3</sub>) receptor. Ca<sup>2+</sup> oscillations are induced by a cytosolic sperm factor driven into the egg cytoplasm upon sperm-egg fusion. A current strong candidate of the sperm factor is a novel sperm-specific isozyme of phospholipase C (IP<sub>3</sub>-producing enzyme), PLCζ. Recent extensive research has reveled characteristics of PLCζ such as the Ca<sup>2+</sup> oscillation-inducing activity after injection of PLCζ-encoding RNA or recombinant PLCζ into mouse eggs, extremely high Ca<sup>2+</sup>-sensitivity of the enzymatic activity in vitro, and nuclear translocation ability possibly related to cell-cycle-dependent regulation of Ca<sup>2+</sup> oscillations. [Ca<sup>2+</sup>]<sub>i</sub> rises cause successive activation of calmodulin-dependent kinase II and E3 ubiquitin ligase, lead to proteolysis of ubiquitinated cyclin B1 and inactivation of metaphase-promoting factor (Cdk1/cyclin B1 complex), and result in the release of eggs from meiotic arrest.<br>

収録刊行物

  • Journal of pharmacological sciences  

    Journal of pharmacological sciences 100(5), 545-552, 2006-05-15 

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10018239681
  • NII書誌ID(NCID)
    AA11806667
  • 本文言語コード
    ENG
  • 資料種別
    REV
  • ISSN
    13478613
  • NDL 記事登録ID
    7963320
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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