Effects of Intra-arterial Urokinase on a Non-human Primate Thromboembolic Stroke Model
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- Susumu Teruo
- Shin Nippon Biomedical Laboratories (SNBL), Ltd., Japan
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- Yoshikawa Tetsuya
- Shin Nippon Biomedical Laboratories (SNBL), Ltd., Japan
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- Akiyoshi Yuki
- Shin Nippon Biomedical Laboratories (SNBL), Ltd., Japan
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- Nagata Ryoichi
- Shin Nippon Biomedical Laboratories (SNBL), Ltd., Japan
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- Fujiwara Michihiro
- Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
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- Kito Go
- Shin Nippon Biomedical Laboratories (SNBL), Ltd., Japan
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One of the most important prognostic factors in the thrombolytic treatment of acute ischemic stroke is to recanalize. The purpose of this study was to evaluate the effectiveness and safety of urokinase in a primate thromboembolic stroke model. Thromboembolic stroke was accomplished via occlusion of the middle cerebral artery (MCA) obtained by injecting an autologous blood clot into the left internal carotid artery in 21 male cynomolgus monkeys. Animals were randomly assigned to the following treatment groups: Group 1: vehicle (saline), Group 2: urokinase (40,000 IU), Group 3: urokinase (120,000 IU,) over 2 or 6 h via intra-internal carotid catheter starting 1 h after embolization, respectively. In the urokinase-treated groups, neurologic deficits were improved in consciousness and skeletal muscle coordination, but not sensory and motor systems. The infarction size in Group 2 (11.9 ± 3.9% of the hemisphere) and 3 (7.6 ± 2.5%) were significantly smaller than that (24.7 ± 3.5%) in Group 1. However, 2 of 5 animals in Group 3 died. In conclusion, urokinase improved neurologic deficits and reduced cerebral infarction on thromboembolic stroke in the cynomolgus monkey.<br>
収録刊行物
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 100 (4), 278-284, 2006
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282680154349952
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- NII論文ID
- 10018239912
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- NII書誌ID
- AA11806667
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- ISSN
- 13478648
- 13478613
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- NDL書誌ID
- 7884934
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- 使用不可