Role of Substance P on Histamine H_3 Antagonist-Induced Scratching Behavior in Mice

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著者

    • Inoue Toshio INOUE Toshio
    • Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
    • FUJII Yoko
    • Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
    • KAMEI Chiaki
    • Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

抄録

The purpose of the present study was to investigate the involvement of chemical mediators, other than histamine, in the scratching behavior induced by H<sub>3</sub> antagonists. Scratching behavior was induced by the histamine H<sub>3</sub> antagonists iodophenpropit and clobenpropit (10 nmol/site) when they were injected intradermally into the rostral part of the back of mast-cell-deficient (WBB6F1 W/W<sup>v</sup>) and wild-type (WBB6F1 +/+) mice. Subsequently, the effect of spantide, a tachykinin NK<sub>1</sub> antagonist, was measured for 60 min. The effects of the H<sub>3</sub> antagonists on in vitro histamine release from rat peritoneal mast cells were also investigated. When spantide was injected intradermally at a dose of 0.5 nmol/site, it significantly inhibited the response. Furthermore, iodophenpropit and clobenpropit (10<sup>−</sup><sup>6</sup> – 10<sup>−</sup><sup>8</sup> M) did not induce histamine release in isolated rat peritoneal mast cells. Our results indicate that substance P is involved in the skin responses elicited by the histamine H<sub>3</sub> antagonists. Moreover, the fact that these histamine H<sub>3</sub> antagonists did not induce significant increases in the histamine release from rat peritoneal mast cells suggests that the histamine H<sub>3</sub> receptor may not be present in the peripheral cells considered in this study.<br>

収録刊行物

  • Journal of pharmacological sciences  

    Journal of pharmacological sciences 100(4), 297-302, 2006-04-20 

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10018239991
  • NII書誌ID(NCID)
    AA11806667
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13478613
  • NDL 記事登録ID
    7884968
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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