Peripheral Antinociception by Carbamazepine in an Inflammatory Mechanical Hyperalgesia Model in the Rat : a New Target for Carbamazepine?
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This study investigated whether carbamazepine could produce local peripheral antinociception in a rat model of inflammatory mechanical hyperalgesia, and whether adenosine receptors are involved. Carbamazepine (100 – 1000 nmol/paw) coadministrated with a pro-inflammatory compound, concanavalin A, into the hind paw caused a significant dose- and time-dependent anti-hyperalgesia. Coadministration of caffeine (250 – 1000 nmol/paw), a nonselective adenosine-receptor antagonist, as well as DPCPX (10 – 30 nmol/paw), a selective adenosine A<sub>1</sub>-receptor antagonist, with carbamazepine, significantly depressed its anti-hyperalgesic effect. Drugs injected into the contralateral hind paw did not produce significant effects. These results suggest that carbamazepine produces local peripheral anti-hyperalgesia via peripheral adenosine A<sub>1</sub> receptors.<br>
- The Japanese Journal of Pharmacology
The Japanese Journal of Pharmacology 100(4), 310-314, 2006-04-20
The Japanese Pharmacological Society