Peripheral Antinociception by Carbamazepine in an Inflammatory Mechanical Hyperalgesia Model in the Rat: a New Target for Carbamazepine?

  • Vuckovic Sonja
    Department of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, Serbia and Montenegro
  • Tomic Maja
    Department of Pharmacology, Faculty of Pharmacy, University of Belgrade, Serbia and Montenegro
  • Stepanovic-Petrovic Radica
    Department of Pharmacology, Faculty of Pharmacy, University of Belgrade, Serbia and Montenegro
  • Ugrešic Nenad
    Department of Pharmacology, Faculty of Pharmacy, University of Belgrade, Serbia and Montenegro
  • Prostran Milica
    Department of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, Serbia and Montenegro
  • Boškovic Bogdan
    Medical Military Academy, Serbia and Montenegro

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Abstract

This study investigated whether carbamazepine could produce local peripheral antinociception in a rat model of inflammatory mechanical hyperalgesia, and whether adenosine receptors are involved. Carbamazepine (100 – 1000 nmol/paw) coadministrated with a pro-inflammatory compound, concanavalin A, into the hind paw caused a significant dose- and time-dependent anti-hyperalgesia. Coadministration of caffeine (250 – 1000 nmol/paw), a nonselective adenosine-receptor antagonist, as well as DPCPX (10 – 30 nmol/paw), a selective adenosine A1-receptor antagonist, with carbamazepine, significantly depressed its anti-hyperalgesic effect. Drugs injected into the contralateral hind paw did not produce significant effects. These results suggest that carbamazepine produces local peripheral anti-hyperalgesia via peripheral adenosine A1 receptors.<br>

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