Peripheral Antinociception by Carbamazepine in an Inflammatory Mechanical Hyperalgesia Model in the Rat: a New Target for Carbamazepine?
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- Vuckovic Sonja
- Department of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, Serbia and Montenegro
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- Tomic Maja
- Department of Pharmacology, Faculty of Pharmacy, University of Belgrade, Serbia and Montenegro
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- Stepanovic-Petrovic Radica
- Department of Pharmacology, Faculty of Pharmacy, University of Belgrade, Serbia and Montenegro
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- Ugrešic Nenad
- Department of Pharmacology, Faculty of Pharmacy, University of Belgrade, Serbia and Montenegro
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- Prostran Milica
- Department of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, Serbia and Montenegro
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- Boškovic Bogdan
- Medical Military Academy, Serbia and Montenegro
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Abstract
This study investigated whether carbamazepine could produce local peripheral antinociception in a rat model of inflammatory mechanical hyperalgesia, and whether adenosine receptors are involved. Carbamazepine (100 – 1000 nmol/paw) coadministrated with a pro-inflammatory compound, concanavalin A, into the hind paw caused a significant dose- and time-dependent anti-hyperalgesia. Coadministration of caffeine (250 – 1000 nmol/paw), a nonselective adenosine-receptor antagonist, as well as DPCPX (10 – 30 nmol/paw), a selective adenosine A1-receptor antagonist, with carbamazepine, significantly depressed its anti-hyperalgesic effect. Drugs injected into the contralateral hind paw did not produce significant effects. These results suggest that carbamazepine produces local peripheral anti-hyperalgesia via peripheral adenosine A1 receptors.<br>
Journal
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 100 (4), 310-314, 2006
The Japanese Pharmacological Society
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Details
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- CRID
- 1390001205177641984
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- NII Article ID
- 10018240041
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- NII Book ID
- AA11806667
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- ISSN
- 13478648
- 13478613
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- NDL BIB ID
- 7885000
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed