Inhibitory Effects of Bisphosphonates on the Differentiation and Activity of Osteoclasts
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- Suzuki Keiko
- Department of Pharmacology, School of Dentistry, Showa University, Japan
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- Takeyama Sadaaki
- Division of Pharmacology, Department of Oral Biology, Tohoku University Graduate School of Dentistry, Japan
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- Sakai Yasushi
- Division of Physiology, School of Nursing and Rehabilitation Sciences, Showa University, Japan
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- Yamada Shoji
- Department of Pharmacology, School of Dentistry, Showa University, Japan
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- Shinoda Hisashi
- Division of Pharmacology, Department of Oral Biology, Tohoku University Graduate School of Dentistry, Japan
書誌事項
- タイトル別名
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- Current Topics in Pharmacological Research on Bone Metabolism: Inhibitory Effects of Bisphosphonates on the Differentiation and Activity of Osteoclasts
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抄録
Despite the extensive use of bisphosphonates (BPs) in the treatment of metabolic bone diseases associated with increased osteoclastic bone resorption, the precise mechanism of their action on bone metabolism is still unclear. To clarify at which stages of osteoclast differentiation and activation that BPs influence, we examined the osteoclasts generated from mononuclear precursors and osteoclasts in the calvaria by laser scanning confocal microscopy. The studies showed that BPs inhibit lipopolysaccharide- or parathyroid hormone-induced osteoclast differentiation, fusion, attachment, actin ring formation, and activation and that both β3 integrin and osteopontin have an important role in cytoskeletal rearrangements associated with cell attachment and resorption in osteoclasts.<br>
収録刊行物
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 100 (3), 189-194, 2006
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001205176540800
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- NII論文ID
- 10018240255
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- NII書誌ID
- AA11806667
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- ISSN
- 13478648
- 13478613
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- NDL書誌ID
- 7858192
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可