Current Topics in Pharmacological Research on Bone Metabolism: Regulation of Bone Mass by the Function of Endogenous Modulators of Bone Morphogenetic Protein in Adult Stage
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- Noda Masaki
- Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Japan
Bibliographic Information
- Other Title
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- Regulation of Bone Mass by the Function of Endogenous Modulators of Bone Morphogenetic Protein in Adult Stage
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Abstract
Bone formation in adults determines the basic mass of bone and hence it is crucial to understand the mechanisms of its regulation. As remodeling is proceeding, bone resorption is determined by the physical conditions. Especially in women, postmenopausal bone loss is characterized by rapid bone loss due to increase in bone resorption and relative negative balance between such bone resorption and accelerated bone formation. Bone formation is also critical in considering measures to treat patients with very low bone mass. In these subjects, simple suppression of bone resorption would not be enough to maintain bone mass. Thus, bone formation in the adult is of importance in terms of both pathological and therapeutic aspects. This review addresses the possible roles of bone formation modulators in the maintenance of bone mass in the light of understanding the determination of adult bone mass.<br>
Journal
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 100 (3), 211-214, 2006
The Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390001205176536704
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- NII Article ID
- 10018240368
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- NII Book ID
- AA11806667
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- ISSN
- 13478648
- 13478613
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- NDL BIB ID
- 7858245
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed