Hypersensitivity to Hydroxyl Radicals in Rat Basilar Artery After Subarachnoid Hemorrhage

• Nishihashi Tsuyoshi

  Pharmacology Division, RI Center, Kyoto University, Japan

• Trandafir Cristina C.

  Pharmacology Division, RI Center, Kyoto University, Japan

• Wang Aimin

  Pharmacology Division, RI Center, Kyoto University, Japan

• Ji Xu

  Pharmacology Division, RI Center, Kyoto University, Japan

• Shimizu Yoshiharu

  Department of Community Health, School of Medicine, Tokai University, Japan

• Kurahashi Kazuyoshi

  Pharmacology Division, RI Center, Kyoto University, Japan

抄録

Vasospasm after subarachnoid hemorrhage (SAH) is a serious complication and we have been investigating the relationship between vasoconstrictors and vasospasm after SAH. The present study was designed to investigate the vasocontractile responses to reactive oxygen species in isolated rat basilar arteries from the control and experimental SAH rats. Contractile responses to hydroxyl radicals in basilar arteries from SAH rats were 3 – 6-fold higher than those in control rats. The present results clearly indicate that hypersensitivity to hydroxyl radicals may contribute to the vasospasm after SAH.<br>

収録刊行物

• Journal of Pharmacological Sciences

  Journal of Pharmacological Sciences 100 (3), 234-236, 2006

  公益社団法人 日本薬理学会

キーワード

• subarachnoid hemorrhage
• hydroxyl radical
• rat basilar artery

詳細情報

• CRID: 1390282680153241984
• NII論文ID: 10018240436
• NII書誌ID: AA11806667
• DOI: 10.1254/jphs.sc0050160
• ISSN: 13478648
• ISSN: 13478613
• NDL書誌ID: 7858283
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7858283
• Web Site: https://search.jamas.or.jp/link/ui/2007051033
• 本文言語コード: en
• データソース種別:
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  • NDL
  • Crossref
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