Voltage-Dependent Ca^<2+>-Channel Block by Openers of Intermediate and Small Conductance Ca^<2+>-Activated K^+ Channels in Urinary Bladder Smooth Muscle Cells

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著者

    • Morimura Kozo MORIMURA Kozo
    • Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University
    • IMAIZUMI Yuji
    • Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University

抄録

We examined effects of small and intermediate conductance Ca<sup>2+</sup>-activated K<sup>+</sup> (SK and IK) channel openers, DCEBIO (5,6-dichloro-1-ethyl-1,3-dihydro-2<i>H</i>-benzimidazol-2-one) and NS309 (3-oxime-6,7-dichloro-1<i>H</i>-indole-2,3-dione), on L-type Ca<sup>2+</sup> channel current (I<sub>Ca</sub>) that was measured in smooth muscle cells isolated from mouse urinary bladder under whole cell voltage-clamp. The I<sub>Ca</sub> was concentration-dependently inhibited by DCEBIO and NS309; half inhibition was obtained at 71.6 and 10.6 μM, respectively. The specificity of NS309 to the IK channel over the Ca<sup>2+</sup> channel appears to be high and higher than that of DCEBIO. DCEBIO and even NS309 may, however, substantially block Ca<sup>2+</sup> channels when used as SK channel openers.<br>

収録刊行物

  • Journal of pharmacological sciences  

    Journal of pharmacological sciences 100(3), 237-241, 2006-03-20 

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10018240450
  • NII書誌ID(NCID)
    AA11806667
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    13478613
  • NDL 記事登録ID
    7858299
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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