Inhibitory Mechanism of Monensin on High K^+-Induced Contraction in Guniea-Pig Urinary Bladder

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In this study, we examined the inhibitory mechanism of monensin on high K<sup>+</sup>-induced contraction in guinea-pig urinary bladder. The relaxant effect of monensin (0.001 – 10 μM) was more potent than those of NaCN (100 μM – 1 mM) and forskolin (3 – 10 μM). Monensin (0.1 μM), NaCN (300 μM), or forskolin (10 μM) inhibited high K<sup>+</sup>-induced contraction without decreasing [Ca<sup>2+</sup>]<sub>i</sub> level. Monensin and NaCN remarkably decreased creatine phosphate and ATP contents. Monensin and NaCN inhibited high K<sup>+</sup>-induced increases in flavoprotein fluorescence, which is involved in mitochondrial respiration. Forskolin increased cAMP content but monensin did not. Monensin increased Na<sup>+</sup> content at 10 μM but not at 0.1 μM that induced maximum relaxation. In the α-toxin-permeabilized muscle, forskolin significantly inhibited the Ca<sup>2+</sup>-induced contraction, but monensin did not affect it. These results suggest that the relaxation mechanism of monensin in smooth muscle of urinary bladder may be an inhibition of oxidative metabolism.<br>

収録刊行物

  • Journal of pharmacological sciences  

    Journal of pharmacological sciences 100(2), 133-141, 2006-02-20 

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10018240726
  • NII書誌ID(NCID)
    AA11806667
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13478613
  • NDL 記事登録ID
    7821850
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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