Generalization of NMDA-Receptor Antagonists to the Discriminative Stimulus Effects of .KAPPA.-Opioid Receptor Agonists U-50,488H, but Not TRK-820 in Rats

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  • Mori Tomohisa
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Japan Department of Legal Medicine, Tokyo Women’s Medical University, Japan
  • Nomura Mutsuko
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Japan
  • Yoshizawa Kazumi
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Japan
  • Nagase Hiroshi
    Basic Research Laboratories, Toray Industries, Inc., Japan
  • Sawaguchi Toshiko
    Department of Legal Medicine, Tokyo Women’s Medical University, Japan
  • Narita Minoru
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Japan
  • Suzuki Tsutomu
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Japan

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Other Title
  • Generalization of NMDA-Receptor Antagonists to the Discriminative Stimulus Effects of κ-Opioid Receptor Agonists U-50,488H, but Not TRK-820 in Rats
  • Generalization of NMDA Receptor Antagonists to the Discriminative Stimulus Effects of カッパ Opioid Receptor Agonists U 50 488H but Not TRK 820 in Rats
  • Generalization of NMDA-receptor agonists U-50,488H, but not TRK-820 in rats.

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Abstract

Generalizations of NMDA-receptor antagonists to the discriminative stimulus effects of κ-opioid receptor agonists in rats were examined. Phencyclidine, MK-801, and ketamine, non-competitive NMDA-receptor antagonists, generalized to the discriminative stimulus effects of U-50,488H, but not those of TRK-820, whereas (±)-3-(2-carbaxypiperazine-4-yl) propyl-1-phosphonic acid (CPP), a competitive NMDA-receptor antagonist, and ifenprodil, an NR1/NR2B NMDA-receptor antagonist, did not, suggesting that non-competitive NMDA-receptor antagonists possess U-50,488H-like discriminative stimulus effects in rats. Since U-50,488H and phencyclidine both induce aversive effects, our findings indicate that the cue of the discriminative stimulus effects of U-50,488H and non-competitive NMDA-receptor antagonists may be associated with their aversive effects.<br>

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