Induction of Heme Oxygenase-1 Inhibits Monocyte Chemoattractant Protein-1 mRNA Expression in U937 Cells

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著者

    • OMURA Shinji
    • Department of Biomedical Chemistry, Graduate School of Biomedical Sciences, Hiroshima University
    • TOYOFUKU Mamoru
    • Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima University
    • SHIMIZU Yoshito
    • Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima University
    • IMAZU Michinori
    • Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima University
    • KOHNO Nobuoki
    • Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima University

抄録

Heme oxygenase-1 (HO-1) is a stress-inducible isoform of HO with potential cytoprotective effects. Monocyte activation/migration mediated by monocyte chemoattractant protein-1 (MCP-1) is one of the earliest and important events in the pathogenesis of atherosclerosis. We examined the effect of HO-1 on the production of lysophosphatidylcholine (Lyso-PC)-induced MCP-1 in the human promonocytic cell line U937. Increased HO-1 induction by hemin resulted in a significant decrease in the Lyso-PC-mediated induction of MCP-1 mRNA expression. SnPP (IX), the specific inhibitor of HO-1 enzymatic activity, prevented the hemin-mediated attenuation of MCP-1 mRNA expression. These results suggest that HO-1 may work as an anti-atherogenic agent through the attenuation of MCP-1 production.<br>

収録刊行物

  • Journal of pharmacological sciences  

    Journal of pharmacological sciences 100(2), 162-166, 2006-02-20 

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10018240849
  • NII書誌ID(NCID)
    AA11806667
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    13478613
  • NDL 記事登録ID
    7821907
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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