Induction of Heme Oxygenase-1 Inhibits Monocyte Chemoattractant Protein-1 mRNA Expression in U937 Cells

• Shokawa Tomoki

  Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Japan

• Yoshizumi Masao

  Department of Cardiovascular Physiology and Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Japan

• Yamamoto Hideya

  Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Japan

• Omura Shinji

  Department of Biomedical Chemistry, Graduate School of Biomedical Sciences, Hiroshima University, Japan

• Toyofuku Mamoru

  Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Japan

• Shimizu Yoshito

  Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Japan

• Imazu Michinori

  Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Japan

• Kohno Nobuoki

  Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Japan

Abstract

Heme oxygenase-1 (HO-1) is a stress-inducible isoform of HO with potential cytoprotective effects. Monocyte activation/migration mediated by monocyte chemoattractant protein-1 (MCP-1) is one of the earliest and important events in the pathogenesis of atherosclerosis. We examined the effect of HO-1 on the production of lysophosphatidylcholine (Lyso-PC)-induced MCP-1 in the human promonocytic cell line U937. Increased HO-1 induction by hemin resulted in a significant decrease in the Lyso-PC-mediated induction of MCP-1 mRNA expression. SnPP (IX), the specific inhibitor of HO-1 enzymatic activity, prevented the hemin-mediated attenuation of MCP-1 mRNA expression. These results suggest that HO-1 may work as an anti-atherogenic agent through the attenuation of MCP-1 production.<br>

Journal

• Journal of Pharmacological Sciences

  Journal of Pharmacological Sciences 100 (2), 162-166, 2006

  The Japanese Pharmacological Society

Keywords

• heme oxygenase-1
• oxidized low-density lipoprotein
• monocyte chemoattractant protein-1

Details

• CRID: 1390001205177577600
• NII Article ID: 10018240849
• NII Book ID: AA11806667
• DOI: 10.1254/jphs.sc0040188
• ISSN: 13478648
• ISSN: 13478613
• NDL BIB ID: 7821907
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7821907
• Web Site: https://search.jamas.or.jp/link/ui/2006310787
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed