Renoprotective Effect of Rho-Kinase Inhibitor in Hypertensive Glomerulosclerosis

• Nishikimi Toshio

  Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Japan

• Matsuoka Hiroaki

  Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Japan

書誌事項

タイトル別名

• Molecular Mechanisms and Therapeutic Strategies of Chronic Renal Injury: Renoprotective Effect of Rho-Kinase Inhibitor in Hypertensive Glomerulosclerosis

抄録

Among the GTP-binding proteins, Rho is known to function as a molecular switch in various cellular functions. Among the Rho effectors, the cellular function and signal transduction of Rho-kinase have been extensively studied. However, information about its in vivo functions is still limited. With the recent development of a specific Rho-kinase inhibitor such as Y-27632 and fasudil, the understanding of the role of the Rho/Rho-kinase pathway in vitro and in vivo has advanced. However, to date, there have been few studies investigating the role of Rho-kinase in renal disease. Recent studies have shown that Rho-kinase inhibitor significantly attenuated the tubulointerstitial fibrosis in kidney induced by unilateral ureteral obstruction. However, there have been few studies investigating the role of the Rho/Rho-kinase pathway in hypertensive glomerular sclerosis. In this review, we described the role of the Rho/Rho-kinase pathway in the progression of renal glomerulosclerosis in several forms of hypertensive rats. Our results suggest that chronic inhibition of the Rho-kinase pathway may be a new therapeutic approach for hypertensive glomerulosclerosis. Our results also suggest that the mechanism of the renoprotective effect of Rho-kinase inhibitor is partly mediated via inhibition of extracellular matrix gene expression, monocytes/macrophages infiltration, oxidative stress, and upregulation of eNOS gene expression.<br>

収録刊行物

• Journal of Pharmacological Sciences

  Journal of Pharmacological Sciences 100 (1), 22-28, 2006

  公益社団法人 日本薬理学会

キーワード

• fasudil
• Rho-kinase
• hypertension
• transforming growth factor
• glomerulosclerosis

詳細情報

• CRID: 1390282680152043136
• NII論文ID: 10018240967
• NII書誌ID: AA11806667
• DOI: 10.1254/jphs.fmj05003x5
• ISSN: 13478648
• ISSN: 13478613
• NDL書誌ID: 7782935
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7782935
• Web Site: https://search.jamas.or.jp/link/ui/2006280749
• 本文言語コード: en
• データソース種別:
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• 抄録ライセンスフラグ: 使用不可