Analysis of Vasoreactivity of Isolated Human Radial Artery

• Stojnic Natasa

  Departement of Clinical Pharmacology, Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, Serbia and Montenegro

• Bukarica Ljiljana Gojkovic

  Departement of Clinical Pharmacology, Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, Serbia and Montenegro

• Peric Miodrag

  Institute for Cardiovascular Diseases “Dedinje”, Serbia and Montenegro

• Bumbasirevic Marko

  Institute for Orthopedics and Traumatology, Clinical Center of Serbia, Serbia and Montenegro

• Lesic Aleksandar

  Institute for Orthopedics and Traumatology, Clinical Center of Serbia, Serbia and Montenegro

• Lipkovski Jasmina Markovic

  Institute of Pathology, Faculty of Medicine, University of Belgrade, Serbia and Montenegro

• Heinle Helmut

  Institute of Physiology, University of Tubingen, Germany

抄録

Radial artery (RA) is increasingly used as graft for coronary artery bypass grafting due to its good long-term patency. However, the mechanism of peri- and post-operative spasm is still unclear. Because of that, the aim of our study is to analyze the contractility of RA and to determine whether the presence of functional endothelium alters its contractile properties. Contractions of isolated RA rings were provoked by exogenously applied vasoconstrictors or by electrical field stimulation (EFS, 20 Hz). The order of vasoconstrictors potency based on their EC₅₀ values was as follows: angiotensin II > phenylephrine > 5-hydroxytriptamine. Presence of endothelium increased both EC₅₀ and maximal contraction to phenylephrine and angiotensin II, but inhibited reactivity of RA to 5-hydroxytriptamine. Spontaneous rhythmic contractions (SRC, <4 mHz) and EFS-induced contractions of RA are endothelium-independent and weaker than contractions induced by exogenously applied vasoconstrictors. Our study concludes that RA shows marked sensitivity and reactivity to angiotensin II, phenylephrine, and 5-hydroxytriptamine. Further investigations are necessary to answer why angiotensin II and phenylepehrine induce stronger contractions in the presence of endothelium. In addition, SRC as well as contractions of neurogenic origin may take part in developing vascular spasm of RA.<br>

収録刊行物

• Journal of Pharmacological Sciences

  Journal of Pharmacological Sciences 100 (1), 34-40, 2006

  公益社団法人 日本薬理学会

キーワード

• human radial artery
• angiotensin II
• phenylephrine
• 5-hydroxytriptamine
• vasomotion
• electrical field stimulation

詳細情報

• CRID: 1390282680152035968
• NII論文ID: 10018241025
• NII書誌ID: AA11806667
• DOI: 10.1254/jphs.fpe05004x
• ISSN: 13478648
• ISSN: 13478613
• NDL書誌ID: 7782968
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7782968
• Web Site: https://search.jamas.or.jp/link/ui/2006280751
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可