Lysophosphatidic Acid (LPA) Induces Plasma Exudation and Histamine Release in Mice via LPA Receptors

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Lysophosphatidic acid (LPA), the simplest of the water-soluble phospholipids, can evoke various biological responses. The present study examined the activity of LPA to induce plasma exudation and histamine release in mice. Plasma exudation was assessed by extravasation of Evans blue. Subcutaneous administration of LPA (1 – 100 μg/site) led to increased plasma exudation in the skin. The LPA-induced plasma exudation was inhibited by ketotifen, a histamine H<sub>1</sub>-receptor antagonist, and diacylglycerol pyrophosphate (DGPP), a LPA<sub>1</sub>/LPA<sub>3</sub>-receptor antagonist. Moreover, pretreatment with pertussis toxin and DGPP inhibited the histamine release from peritoneal mast cells induced by LPA. These findings indicate that plasma exudation induced by LPA is mediated by histamine release from mast cells via LPA receptor(s), presumably LPA<sub>1</sub> and/or LPA<sub>3</sub>, coupled to G<sub>i/o</sub> proteins. Moreover, these findings point to a role of LPA in the pathomechanisms of various allergic disorders.<br>

収録刊行物

  • Journal of pharmacological sciences  

    Journal of pharmacological sciences 100(1), 82-87, 2006-01-20 

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10018241238
  • NII書誌ID(NCID)
    AA11806667
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13478613
  • NDL 記事登録ID
    7783084
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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