Lysophosphatidic Acid (LPA) Induces Plasma Exudation and Histamine Release in Mice via LPA Receptors
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- Hashimoto Terumasa
- Department of Pharmacology, School of Pharmaceutical Sciences, Showa University, Japan
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- Ohata Hisayuki
- Department of Pharmacology, School of Pharmaceutical Sciences, Showa University, Japan
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- Honda Kazuo
- Department of Pharmacology, School of Pharmaceutical Sciences, Showa University, Japan
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抄録
Lysophosphatidic acid (LPA), the simplest of the water-soluble phospholipids, can evoke various biological responses. The present study examined the activity of LPA to induce plasma exudation and histamine release in mice. Plasma exudation was assessed by extravasation of Evans blue. Subcutaneous administration of LPA (1 – 100 μg/site) led to increased plasma exudation in the skin. The LPA-induced plasma exudation was inhibited by ketotifen, a histamine H1-receptor antagonist, and diacylglycerol pyrophosphate (DGPP), a LPA1/LPA3-receptor antagonist. Moreover, pretreatment with pertussis toxin and DGPP inhibited the histamine release from peritoneal mast cells induced by LPA. These findings indicate that plasma exudation induced by LPA is mediated by histamine release from mast cells via LPA receptor(s), presumably LPA1 and/or LPA3, coupled to Gi/o proteins. Moreover, these findings point to a role of LPA in the pathomechanisms of various allergic disorders.<br>
収録刊行物
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 100 (1), 82-87, 2006
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001205175294976
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- NII論文ID
- 10018241238
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- NII書誌ID
- AA11806667
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- ISSN
- 13478648
- 13478613
- http://id.crossref.org/issn/13478613
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- NDL書誌ID
- 7783084
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
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- 使用不可