書誌事項
- タイトル別名
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- Antihypertensive Effect of .GAMMA.-Aminobutyric Acid-Enriched Agaricus blazei on Spontaneously Hypertensive Rats.
- コウケツアツ シゼン ハッショウ ラット ニ オケル ガンマ アミノラクサン チクセキ アガリクスダケ ノ ケツアツ コウカ サヨウ
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The effect of γ-aminobutyric acid (GABA)-enriched Agaricus blazei (AG-GABA) and mycelia of Agaricus blazei (AG-M) on blood pressure of spontaneously hypertensive rats (SHR) was studied. Powdered AG-GABA or AG-M was fed on SHR at the levels of 5% (Experiment-A) or 2% (Experiment-B) in a 1% NaCl (control) diet for 21 or 28 days and that systolic and diastolic blood pressure were measured by tail cuff. Animals of AG-GABA and AG-M groups showed significantly lower blood pressure compared to the control group. AG-GABA had stronger hypotensive effect than AG-M. The serum levels of total cholesterol (TC) and triglyceride of groups fed AG-GABA and AG-M were lower than those of the control group, and atherogenic index [(TC-HDL-C)/HDL-C] was improved in 21 or 28 days. The inhibitory activity of the angiotensin I-converting enzyme (ACE) was compared among of AG-GABA, AG-M and GABA. The IC50 of AG-GABA and AG-M for ACE were 1.9 and 1.7 mg/ml, respectively. However, GABA showed no inhibitory activity against the ACE. These phenomena suggested that AG-GABA has concomitant hypotensive effects by GABA and ACE inhibitory substance (unknown).
収録刊行物
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- 日本食品科学工学会誌
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日本食品科学工学会誌 49 (3), 166-173, 2002
公益社団法人 日本食品科学工学会
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詳細情報 詳細情報について
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- CRID
- 1390001206409255296
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- NII論文ID
- 10018254921
- 10007835951
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- NII書誌ID
- AN10467499
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- COI
- 1:CAS:528:DC%2BD38XjtlyrsLc%3D
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- ISSN
- 18816681
- 1341027X
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- NDL書誌ID
- 6108892
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
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- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可