環境医学領域におけるプロテオミクスの導入  [in Japanese] Introduction of Proteomic Approach to Environmental Medicine  [in Japanese]

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Author(s)

    • 日吉 峰麗 HIYOSHI Mineyoshi
    • 徳島大学大学院ヘルスバイオサイエンス研究部先端基礎医学教育研究プロジェクト Education and Research Projects for Cutting-Edge Basic Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
    • 上村 浩一 UEMURA Hirokazu
    • 徳島大学大学院ヘルスバイオサイエンス研究部社会環境衛生学講座予防医学分野 Department of Preventive Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
    • 武田 英雄 [他] TAKEDA Hideo
    • 徳島大学大学院ヘルスバイオサイエンス研究部社会環境衛生学講座予防医学分野 Department of Preventive Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School
    • 木戸 博 KIDO Hiroshi
    • 徳島大学分子酵素学研究センター酵素分子化学部門 Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima
    • 有澤 孝吉 ARISAWA Kokichi
    • 徳島大学大学院ヘルスバイオサイエンス研究部社会環境衛生学講座予防医学分野 Department of Preventive Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School

Abstract

Recent progress in life science technology and the availability of much information on genes obtained by genome analysis has enabled us to analyze the changes of proteins on a large scale. Sets of proteins are called proteomes, and proteomics is the scientific field of proteome analysis including differential, post translational modification and interaction analyses. Various proteomic techniques, particularly two-dimensional gel electrophoresis (2-DE), mass spectrometry, protein chip methods, and surface plasmon resonance (SPR), are very useful for acquiring proteomes in cells, tissues and body fluid, and for analyzing interactions between a protein and other biofactors including proteins. A proteomic approach is also useful for determining biomarkers of diseases and key proteins involved in various stages of metabolism such as differentiation, cell cycle and apoptosis. Environmental pollutants including endocrine disruptors inhibit activities of various organs in wild animals and humans. Proteomic approaches could be very useful tools for elucidating the mechanisms of damage caused by environmental pollutants. In this review, we describe the application of a proteomic approach to the field of environmental medicine.

Journal

  • Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene)  

    Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene) 61(4), 393-399, 2006-08-15 

    The Japanese Society for Hygiene

References:  13

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Codes

  • NII Article ID (NAID)
    10018256506
  • NII NACSIS-CAT ID (NCID)
    AN00185923
  • Text Lang
    JPN
  • Article Type
    REV
  • ISSN
    00215082
  • NDL Article ID
    8526012
  • NDL Source Classification
    ZS17(科学技術--医学--衛生学・公衆衛生)
  • NDL Call No.
    Z19-194
  • Data Source
    CJP  NDL  J-STAGE 
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