A fatal case of severe acute exacerbation due to hepatitis B virus with YMDD motif mutation

• Shibata Hidetaka

  First department of internal medicine, Nagasaki University School of Medicine

• Ichikawa Tatsuki

  First department of internal medicine, Nagasaki University School of Medicine

• Nakao Kazuhiko

  First department of internal medicine, Nagasaki University School of Medicine

• Motoyoshi Yasuhide

  First department of internal medicine, Nagasaki University School of Medicine

• Kawashimo Hiroshi

  First department of internal medicine, Nagasaki University School of Medicine

• Fukuta Mariko

  First department of internal medicine, Nagasaki University School of Medicine

• Goto Takashi

  First department of internal medicine, Nagasaki University School of Medicine

• Taura Naota

  First department of internal medicine, Nagasaki University School of Medicine

• Nishimura Daisuke

  First department of internal medicine, Nagasaki University School of Medicine

• Hamasaki Keisuke

  First department of internal medicine, Nagasaki University School of Medicine

• Okubo Kazuaki

  Department of internal medicine, Sasebo Chuo hospital

• Eguchi Katsumi

  First department of internal medicine, Nagasaki University School of Medicine

Bibliographic Information

Other Title

• ＹＭＤＤ変異株による急性増悪のため死亡したＢ型肝硬変の１例
• 症例報告 YMDD変異株による急性増悪のため死亡したB型肝硬変の1例
• ショウレイ ホウコク YMDD ヘンイシュ ニ ヨル キュウセイ ゾウオ ノ タメ シボウ シタ Bガタ カンコウヘン ノ 1レイ

Abstract

A 54-year-old woman was diagnosed as decompensated cirrhosis due to hepatitis B virus (HBV) in August 2001. Administration of Lamivudine was started in September 2001 and lead to undetectable HBV DNA level in serum in August 2002, accompanied by clinical and biochemical improvement. In January 2003, severe acute exacerbation developed, following increased HBV-DNA level. She had biochemical and virological improvement by conservative management. In January 2004, HBV DNA level again increased but ALT level remained normal. In September 2004, severe acute exacerbation developed and adefovir was readily administered. Although plasmapheresis and continuous hemodiafiltration were carried out, hepatic failure and encephalopathy worsened. She was complicated by bacterial pneumoniae and died in October 2004. Our case is thought to give an important information about timing of administration of adefovir for YMDD mutant.<br>

Journal

• Kanzo

  Kanzo 47 (7), 329-333, 2006

  The Japan Society of Hepatology

Keywords

• YMDD mutant
• hepatitis B
• hepatic failure
• lamivudine
• adefovir

Details

• CRID: 1390282679767646976
• NII Article ID: 10018264623
• NII Book ID: AN00047770
• DOI: 10.2957/kanzo.47.329
• ISSN: 18813593
• ISSN: 04514203
• NDL BIB ID: 7990986
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7990986
• Web Site: http://www.jstage.jst.go.jp/article/kanzo/47/7/47_7_329/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2006274542
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed