A case of severe autoimmune hepatitis triggered by discontining long term Celestamine treatment

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  • セレスタミンを長期内服し休薬後に重症自己免疫性肝炎を発症した１例
  • 症例報告 セレスタミンを長期内服し休薬後に重症自己免疫性肝炎を発症した1例
  • ショウレイ ホウコク セレスタミン オ チョウキ ナイフク シ キュウヤク ゴ ニ ジュウショウ ジコ メンエキセイ カンエン オ ハッショウ シタ 1レイ

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Abstract

The patient was a 70-year-old man. He had been treated with Celestamine® about three years for his chronic sinusitis. He was admitted to our hospital for his clinical symptoms including nausea, pruritus, and yellow urine. We diagnosed autoimmune hepatitis from the examinations and clinical course. At first, we treated him with UDCA (600mg/day). His general condition was not well for several days, so we then treated him with PSL (30mg/day), where upon he improved. The pathological findings showed inflammation cell permeation and rosette formation. It was thought that his discontinuation of Celestamine® triggered deterioration resulting in serious autoimmune hepatitis. Moreover, much remains unclear as to the implications of the excess iron deposits in liver tissue in terms of autoimmune hepatitis. Thus, further investigations are necessary in this regard.<br>

Journal

  • Kanzo

    Kanzo 47 (7), 341-346, 2006

    The Japan Society of Hepatology

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